Thursday, March 15, 2012

Margarito stops Cotto in 11th, takes crown

Antonio Margarito showed he is the world's best welterweight by stopping Miguel Cotto to win the WBA title Saturday.

The Mexican, who had also won the IBF version of the title in April, inflicted Cotto's first defeat and took his WBA belt with a late barrage of punches that ended the contest in the penultimate 11th round.

Margarito, the 30-year-old so often ducked by the division's best fighters in recent years, dropped the Puerto Rican champion twice in the 11th after several rounds of relentless pressure at the MGM Grand Garden.

"I told my corner I would wear him down and then knock him out," said Margarito. "He never hurt me, …

United Bank may receive $197 million from rescue plan: ; The company will vote on whether to issue preferred stock

United Bankshares Inc. may be eligible to receive about $197million from the federal government's $700 billion rescue plan, thecompany said in a statement filed with the federal Securities andExchange Commission.

As previously reported, United has called a Dec. 23 specialmeeting of shareholders to vote on whether to amend the company'sarticles of incorporation to allow the company to issue preferredstock. The federal government has been investing in banks bypurchasing preferred stock.

Congress passed the federal rescue plan on Oct. 3. Formallycalled the Capital Purchase Program, it is aimed at persuadinghealthy banks to lend again.

In its proxy statement …

Sam Gilliam

WASHINGTON, DC

CORCORAN GALLERY OF ART / MARSHA MATEYKA GALLERY

Sam Gilliam, an innovative abstract painter and �minence grise of Washington, DC's artistic community, is currently the subject of a stimulating retrospective at the Corcoran Gallery of Art. Gilliam is known principally for his giant "draped" paintings and as an AfricanAmerican artist who gained fame during a period of enormous racial tension. But as Jonathan P. Binstock, the organizer of the exh�btion, demonstrates, the artist has spent more than forty years experimenting with color, shape, and texture, breaking down numerous barriers between painting and sculpture in the process.

Gilliam's content …

National Hockey League Standings

W L OT Pts GF GA
New Jersey 38 19 3 79 182 151
Philadelphia 31 17 9 71 189 169
N.Y. Rangers 31 23 7 69 151 170
Pittsburgh 29 26 6 64 185 191
N.Y. Islanders 18 35 6 42 144 198
Northeast Division
W L OT Pts GF GA
Boston 40 12 8 88 200 137
Montreal 31 22 7 69 184 184
Buffalo 31 23 6 …

Wednesday, March 14, 2012

She needs to work out her past, then stick with the buddy system

DEAR ELLIE: My good friend doesn't accept that I only want him asa buddy. He keeps thinking I'll "come around" to see him as aromantic partner. Every so often, I cut off all contact to try andget my message across. Then he'll say he understands and accepts it,we resume our friendship and on it goes.

I don't want to keep hurting him or spend too much time with thiscomfortable friend instead of allowing someone else into my life whomI'd want to marry eventually. I was hurt badly by my ex, so I've beenextra-cautious, and so far have only been able to have a couple offriendships with men.

LIMITED BUDDY

DEAR LIMITED BUDDY: Your Comfort Friend is getting double …

Official recommends Va. wind farm

ROANOKE - A state hearing examiner has recommended construction ofthe first utility-grade wind farm in Virginia, provided it meetsconditions to minimize harm to the environment.

The recommendation announced Thursday goes to the StateCorporation Commission, which will decide whether to approveconstruction of the 19-turbine development on Highland County ridges.

SCC hearing examiner Alexander Skirpan found that the project byHighland New Wind Development poses a risk to bats and birds, butsaid a monitoring program by the company and a state agency followingconstruction would help reduce the hazard.

Details of the monitoring were left to the developer and …

Old Believers Burying Crash Victims

Alaska's Old Believers are accustomed to struggle. But even for them, these are the most trying of times.

Five followers of the Christian sect, which broke from the Russian Orthodox Church in the 17th century and has been persecuted since, were killed along with their pilot when their small plane crashed Saturday as they returned to Homer to celebrate the Russian Orthodox Christmas.

Ivan Basargin, 38, a married father of five, lost two brothers and two cousins. Instead of celebrating the holiday Monday, he was preparing for the four funerals that will be held Tuesday in his village of Razdolna.

"We are getting …

Sun-Times bucks circulation trend

As most American newspapers reported significant declines in circulation Monday, the Chicago Sun-Times said its daily circulation was "flat" while recording increases on Saturdays and Sundays.

"Basically, people are buying our paper because we continue to offer a great product," said Sun-Times publisher John Barron. "The Chicago Sun-Times consistently delivers unparalleled local news. We have columnists readers know and trust, not to mention the city's best sports coverage."

The Chicago Sun-Times' daily circulation for the six-month period ending in March recorded a slight .04 percent decline, to 312,141.

The Sunday Sun-Times saw its paid circulation rise by 2.8 …

A note to readers

Central Penn Business Journal accepts only electronic versions of press releases and all other announcements, including submissions for our Awards, Calendar, Newsmakers and On the Move sections.

This streamlines our information management and helps us get your news into the paper more quickly.

Here is a rundown of e-mail addresses we use:

Promotions, new hires and board appointments: people@journalpub.com

Free and low-cost seminars and events: …

Shields pitches 1-hitter, Longoria homers as Rays top Angels

James Shields pitched a one-hitter and Evan Longoria's two-run, ninth-inning homer snapped a scoreless tie and gave the Tampa Bay Rays a 2-0 victory over the Los Angeles Angels on Friday night.

Shields (4-2) rebounded from the second-shortest outing of his career to post his second shutout in his past three starts.

The 26-year-old right-hander limited the Angels to Brandon Wood's one-out single in the third and retired the last 17 batters he faced after hitting Erick Aybar with a pitch in the fourth.

Angels starter Jon Garland allowed no runs and four hits in eight innings. He walked three and struck out two before being replaced by Justin Speier …

Big slip in oil fails to lift stocks

NEW YORK -- Investors' concerns over the economy and potentialinflation outweighed a sharp drop in oil prices, sending stocksslightly lower Friday. All three major indexes were lower for theweek as Wall Street's customary year-end rally stalled.

Wall Street was rattled somewhat by the Labor Department's latestProducer Price Index report, which measures wholesale prices. The PPIrose 0.5 percent in November, far less than October's 1.7 percentrise, but still a troublesome indicator of possible inflation.

The sour mood overshadowed a surprising drop in crude oil futures,which came after OPEC agreed to cut oil production by 1 millionbarrels per day. The move was designed …

Quintiles Transnational Corp.

Description

Quintiles Transnational Corp. has been described as "healthcare knowledge in motion." The company is the world's only global cross-discipline resource providing a complete portfolio of health care product development, commercialization, and information solutions. Named to Fortune's " 100 FastestGrowing Companies in the United States" in 1999, Quintiles now offers customers a critical mass of global resources never before assembled in the health care industry.

Quintiles is headquartered near Research Triangle Park, NC, and is a member of the Forbes Platinum 400, the Fortune 1,000, the Business Week Global 1, 000, and the NASDAQ 100 index.

The company's …

GOP recruiters tilting toward center in 2010 races

Dick Cheney and Rush Limbaugh contend the Republican Party needs less moderation and more conservative backbone to win back voters who have been abandoning it in droves.

Leaders of the party's 2010 election efforts are showing they don't think ideological purity is the answer.

In the latest example, key Republican senators jumped this week behind the Senate candidacy of centrist GOP Gov. Charlie Crist of Florida, picking sides a year before the party primary even though another well-established candidate, former state House Speaker Marco Rubio, has stronger conservative credentials.

In other high-profile Senate races, party leaders have encouraged or recruited centrists such as Tom Ridge of Pennsylvania, Rep. Mike Castle of Delaware and Rep. Mark Kirk of Illinois. Ridge opted not to run, while Castle and Kirk are considering 2010 races for the seats that Democratic appointees filled when Vice President Joe Biden and President Barack Obama left the Senate.

The outreach to more moderate candidates is angering many in the party's conservative base, further exposing a rift over the direction Republicans should take after disastrous election losses in 2006 and 2008. Republican leaders such as Limbaugh, the conservative radio host, and Cheney, the former vice president, have warned the party against moving toward the middle as it tries to regain the congressional majorities it enjoyed in the 1990s and early 2000s.

Almost immediately after Crist launched his campaign Tuesday, an influential conservative blogger, Erick Erickson, asked readers to join a new Web-based group called "Not one penny to the National Republican Senatorial Committee."

Erickson explained his reasons on redstate.com: "Getting behind Crist in the Florida primary is wholly unacceptable."

"I think the party is continuing to not get it, and they'll continue to lose elections if they keep acting in bad faith like this," said John Stemberger, a conservative activist who runs the Florida Family Policy Council. "This race in the primary is really going to be a battle for the heart and soul of the party."

Stemberger said Rubio has a good chance of beating Crist in the primary and national Republicans risk losing credibility if that happens. He called it unprecedented for Washington party insiders to intervene so blatantly in a contested primary.

In Florida, Rubio immediately aired a Web video showing Crist and President Barack Obama standing face to face earlier this year promoting Obama's $787 billion stimulus bill, even as more conservative Republican governors were threatening to refuse the federal money on ideological grounds.

"Borrowed money from China and the Middle East, mountains of debt for our children," an announcer says. "Let the debate begin."

But on Capitol Hill, Republicans such as Senate Minority Leader Mitch McConnell of Kentucky and former presidential candidate John McCain of Arizona joined NRSC Chairman John Cornyn of Texas in singing Crist's praises. Sen. Mel Martinez, the retiring Florida Republican whom Crist would replace, went so far as to encourage Rubio to get out of the race.

Martinez acknowledged that some conservatives don't like Crist, a popular governor who nonetheless has upset many conservatives by taking a "live and let live" approach to same-sex civil unions and by refusing to get involved in the Terri Schiavo right-to-die case when he served as the state's attorney general.

"There's never going to be unanimity" in the part, Martinez said, adding that Crist might even attract some Democrats.

"We can look to broaden the party," Martinez said.

The reception for Crist couldn't be more different from the treatment given conservative Republican Pat Toomey in next year's Pennsylvania Senate race. Even after incumbent Republican Sen. Arlen Specter switched parties and became a Democrat last month, Toomey _ a former congressman _ still hasn't received backing from the national party, which instead tried unsuccessfully to get Ridge to seek the seat and has since talked with another moderate, Rep. Jim Gerlach.

Cornyn, the NRSC chairman, said the group's primary goal is to win seats and that it is pursuing candidates who best fit their states. Although the organization rarely takes sides on competitive primaries, he said it wasn't establishing a new precedent by weighing in so early on Crist. He said the group would decide case-by-case whether to offer public support in other races.

Republicans, Cornyn said, must "get away from this attitude that people who disagree 20 or 30 percent of the time somehow are not welcome in the Republican Party, particularly if we're going to maintain our relevance and grow our numbers."

Roger Stone, a Republican political consultant, said the party's choices are being dictated largely by the states that are in play and by the candidates available. He said GOP leaders are taking the right approach by focusing on election results over ideology.

"Our party has the problem now that (Democrats) had in the 1970s, and that is our party base nominates candidates that are too far away from the electorate and cannot win," Stone said. "You can't win with just the right wing."

"I would rather have 51 percent of the Senate and get 70 percent of our agenda done, whereas conservatives sometimes would rather be 100 percent pure and get nothing done," he said.

Stemberger said that philosophy is what led the party to nominate McCain for president last year even though he had lukewarm backing from conservatives. Crist will be in a similar position if he wins the Senate primary, Stemberger said.

"What they've been doing hasn't worked," he said. "Conservatism didn't lose in 2008. There were no conservatives on the ballot to vote for."

Tuesday, March 13, 2012

New Faces Spur Buckeyes to 38-6 Win

COLUMBUS, Ohio - No. 11 Ohio State took its first step toward forgetting the end of last season.

Todd Boeckman played well in his first start replacing Heisman Trophy-winning quarterback Troy Smith and the Buckeyes made just about all the big plays in beating Youngstown State 38-6 on Saturday.

The Buckeyes welcomed the game as a way to put some distance between themselves and the painful memories of a humiliating 41-14 defeat to Florida in the BCS national championship game Jan. 8.

It was the first time the schools met in football, with Youngstown State now a member of the new Football Championship Subdivision, formerly I-AA.

Boeckman, a tall, rangy junior, directed the first four touchdown drives as the Buckeyes steadily pulled away. He completed 17-of-23 passes for 225 yards and two 1-yard TDs.

Dane Sanzenbacher and Taurian Washington, a pair of prized freshmen wide-outs, each scored on their first career receptions, Sanzenbacher's coming on a 3-yard toss from Boeckman and Washington's covering 37 yards from Antonio Henton.

Another freshman, Brandon Saine, the reigning Mr. Football in Ohio, also was part of the coming-out party with 42 yards rushing on 10 carries including a 1-yard touchdown plunge. He jitterbugged in and out of traffic on a 16-yard TD run late in the third quarter that was called back by a holding call.

Trever Robinson, a seldom used fullback, waited five years to see much playing time on offense. But he caught his first career pass and it also went for a TD in the fourth quarter.

Youngstown State, coming off a final-four appearance in the I-AA playoffs last season, didn't wilt before a crowd of 105,038 at Ohio Stadium - the largest ever to see the Penguins play.

Las Vegas marks opening of neon history park

LAS VEGAS (AP) — Las Vegas Mayor Oscar Goodman is celebrating the grand opening of a new city park dedicated to Sin City's historic neon signs.

Goodman will host a ribbon cutting Thursday at the Neon Boneyard Park in downtown Las Vegas.

The $2 million Neon Boneyard Park features a display of the museum's neon signs collected from historic Las Vegas buildings.

Goodman will also oversee the ceremonial groundbreaking for a new visitor's center at the adjacent Neon Museum.

Sharapova defeats qualifier in 1st match at French

Maria Sharapova has reached the second round at the French Open by easily beating a Russian qualifier.

Trying to win the only Grand Slam title missing from her resume, the 12th-seeded Sharapova eliminated 110th-ranked Ksenia Pervak 6-3, 6-2 Tuesday.

Sharapova had won 24 consecutive first-round matches at Grand Slams until being upset at that stage at the Australian Open in January. Now she's starting a new streak.

Sharapova's best showing at Roland Garros was the 2007 semifinals. She missed time this season with a right elbow injury, but won a clay-court tuneup at Strasbourg last weekend.

It was the 18-year-old Pervak's debut in the main draw of a major tournament.

Tornadoes hit Midwest Storms blamed for at least 45 deaths in Oklahoma, Kansas

OKLAHOMA CITY - The death toll reached 45 today after fiercetornadoes de stroyed entire neighborhoods in Oklahoma and Kansas.One monstrous twister chewed across miles of Tornado Alley for fourhours.

The state medical examiner said 40 people were killed in Oklahomaalone in Monday's storms.

The combined death toll makes this the deadliest tornado outbreaksince 90 people were killed on May 31, 1985, in Ohio, Pennsylvaniaand Ont ario.The largest twister formed about 45 miles southwest of OklahomaCity and cut a path at least a half-mile wide. While many tornadoesare short-lived, this one stayed on the ground for about four hours,said Wayne Ruff, a National Weather Service meteorologist. Local TVstations followed it with live broadcasts.The damage "looks like the Murrah Building, but instead of ninestories tall, it's spread out over a large area," Oklahoma Cityassistant fire chief Jon Hansen said, referring to the federalbuilding bombing in 1995.In Washington, White House press secretary Joe Lockhart saidPresident Clinton would act quickly on Oklahoma Gov. Frank Keating'srequest for an emergency declaration. "My heart goes out to thepeople of Oklahoma and Kansas who suffered through a night of terrorand devastation," Clinton said in a statement.More severe thunderstorms with scattered tornadoes rippled acrossthe Plains this morning, and tornado warnings were posted for partsof central Oklahoma. A tornado watch covered much of the rest of thestate.About 150 miles north, a tornado spawned by the same storm systemtossed mobile homes like tin cans, damaged houses and killed atleastfive people in Wichita, Kan., and its suburb of Haysville. Hospitalsreported treating more than 80 people."It is worse than what you can see," said Bob Thompson, a firebattalion chief in Sedgwick County, Kan. "We'll probably find moredeaths. I don't think we've seen the end of it."Chad Harris was with seven people inside his mobile home inHaysville when it was flipped over and demolished. Two of hiscompanions were critically injured."I have no trailer," Harris said. "We all rolled in it. It wasthe worst experience in my life."In Oklahoma, the dead included 11 people in Bridge Creek, about 30miles southwest of Oklahoma City, said Ben Frizzell, spokesman forthe state Office of Emergency Management.Others died in Oklahoma City and nearby Midwest City, Moore, DelCity and Norman."We're really just getting started on the foot-by-foot search,"Clayton Taylor, a Red Cross spokesman, said today in Oklahoma City."We have whole communities that simply aren't there anymore,"Keating told NBC's "Today" show. "It certainly looks like a hugebattle has taken place."The number of houses destroyed in the Oklahoma City areaapproached 2,000. Cars were tossed about and crushed. Natural gasspewed from ruptured lines. Utility poles were splintered intokindling.Hospitals in the Oklahoma City metro area treated 563 people fortornado-related injuries, police Capt. Charles Allen said.The National Severe Storms Laboratory in Norman said the tornadomay have been a mile wide at times. The weather service's DavidAndra predicted the twister would be categorized at least an F4, thesecond-strongest tornado classification, defined as a storm withwindat 207 to 260 mph.The official classification wasn't expected until later this week,after meteorologists survey the damage and compile more data fromthestorm.The system also spawned twisters in north and west Texas, but didno major damage there.The main tornado in Okla homa formed near Chick asha, about 45miles southwest of the capital.It plowed across the flat countryside, toppling trees, powerlines, buildings and cars until it ripped into south Oklahoma City.Television stations went live as soon as the storms formed, usingcameras on the ground and in helicopters, as well as radar, tofollowtheir charge across the state.In suburban Moore, Catherine Meyers hid under a mattress when thestorm hit her home."My mattress didn't help me," she said, bleeding from her head andarm. "I got hit four or five times on the head by something. I'velost a lot of blood."Mary Pat Faris, who weathered the storm in her bathtub, wore anightgown at Del City High School and waited for word about missingfamily members."I heard it," she said. "I heard the popping and then I heard thetrees crunching and then my house was gone."In Kansas, Wichita's tornado tore a 10-mile path that reached 31/4 miles wide. Smaller twisters struck Sumner and Butler counties,as well as other parts of Sedgwick County, but none causedsubstantial damage or injuries.Kansas Gov. Bill Graves declared a state of disaster for SedgwickCounty, while Keat ing declared a state of emergency and activatedtwo National Guard units.Last year, tornadoes killed 42 people around Kissimmee, Fla., onFeb. 22-23, and 34 people died in the area of Birming ham, Ala., onApril 8.

Media lose appeal of news blackout

Several media organizations, including The Associated Press, lost an appeal on Monday to lift a news blackout on a prominent terrorism case in Canada, but lawyers for the media said the court ruling is a partial victory for journalists reporting on preliminary court hearings.

The appeal relates to the arrests in 2006 of the "Toronto 18," a group prosecutors accuse of planning to truck-bomb nuclear power plants and a building housing Canada's spy service. The case made headlines and heightened fears in Canada, where many people believed they are relatively immune from terrorist strikes.

One man has since been found guilty. Seven of those arrested have had their charges either withdrawn or stayed, but a judge imposedin 2006 a restriction on ongoing bail hearings that forbids journalists from explaining why. The trials of 10 adults, including the alleged ringleaders, have yet to begin.

Reporters may attend hearing, but they cannot report on them. Canada's criminal code allows judges to bar the publication of details of bail hearings if the accused requests a ban.

Lawyers for The Associated Press, the Canadian Broadcasting Corp., CTV television and the Toronto Star appealed the blackout before Ontario's Court of Appeal in March.

They argued the media are surrogates for the public in the courtroom and have an obligation to report on the allegations facing the suspects. Paul Schabas, one of the lawyers representing all four media outlets, told the panel of five judges in March that the public should be allowed to hear why the suspects were released.

But in the 3-2 majority decision released Monday Ontario Court of Appeal Justice Kathryn Feldman wrote that an accused person can be granted a publication ban in a preliminary hearing if there is any possibility the case will go to a jury.

Feldman, writing for the majority, ruled the limit on feedom of expression is justified to prevent the potential breach of fair trial rights. The ruling, however, does say that automatic publication bans are not justified if a case is going to be tried by a judge alone. It's up to an accused person whether to have a jury or judge trial.

Schabas said he expects the case to reach the Supreme Court of Canada.

Most of the lawyers for the suspects want the ban to remain. Some said news coverage could bias potential jurors. Others said challenging a publication ban would be an unfair burden for suspects while they are trying to win their release.

Schabas said Monday that because the remaining suspects are still facing potential jury trials the publication bans will remain in place, but he said the ruling is a "major step" in leading to openness and public scrutiny of bail hearings in Canada. He said the two dissenting judges agreed with the media's position.

Schabas said the division in the court demonstrates that these types of cases must be more open. The media and the government can appeal although no decision has been reached.

"The two judges in dissent acknowledge that while there may be some risk to tainting jurors, it's too speculative and it doesn't outweigh the importance of the public's right to know and right to see what happens in bail hearings," Schabas said. "Until now it's really been under a complete cloak of silence."

Schabas said there is also a case in Alberta that challenges the same section of Canada's law on bail hearings and that Canada's Supreme Court will decide whether or not to hear the case on Thursday.

Fred Kozak, the media lawyer in that case, said Monday's ruling will give the Supreme Court more reason to hear the case. He also called it a partial victory and stepping stone to having the issue decided by the Supreme Court.

"Part of the law was struck down. Where an accused is going to face a trial by judge alone there can be no justification for a publication ban," Kozak said.

Iris Fischer, who also represents the four media outlets, called Monday's ruling a partial victory, too, but acknowledged that most cases are tried by a jury.

"If there is even a possibility of a jury trial at that early stage than it's covered by that mandatory ban," Fischer said.

If it becomes clear later that a case will be tried by a judge then the publication ban no longer applies, Fischer said.

_____

Associated Press Writer Charmaine Noronha in Toronto contributed to this report.

Reflections on Good Practices

One of the undoubted highlights of our professional calendar is the s eco nd night of our annual Bio-IT World Conference & Expo, when we host a gala dinner for the announcement and presentation of our Best Practices Awards (see pages 16-28). The winners are profiled elsewhere in this issue, but it is important to note that our judges' decisions were always hard, in some cases contentious even, and it would be a shame to dismiss the dozens of worthy entries merely to champion the nine winners.

Basic Research and Discovery: Working with JMP Genomics, Greg Gibson's laboratory at the Georgia Institute of Technology is developing a high-throughput workflow to study "geographical genomics," or the genetics of gene expression in global populations, with some impressive peerreviewed publications already. Genstruct, a previous winner, impressed again with a causal network model of a liver cancer in a mouse model, in conjunction with Pfizer. And Sigma's partnership with Ingenuity to create a free web-based biological search portal had its admirers.

Knowledge Management: Undoubtedly the most dynamic category, this spurred four awards in all. Among those edged out was Biovista, which is developing a very promising literature-based discovery platform for drug repositioning purposes. The judges were also impressed with HP's ongoing work with the M.D. Anderson Cancer Center in Houston in building a Research Station platform to integrate genomic, transcriptomic and proteomic data. And Tessella presented CrysIS, an X-ray crystallography workflow tool now in worldwide deployment among drug design chemists across AstraZeneca.

In Personal and Translational Medicine, Merck followed up its 2008 Best Practice Award with phase two of its collaboration with the Moifitt Cancer Center, namely the establishment of a "data usability environment" to conduct hypothesis-driven research without the need of IT professionals. Merck also contributed a clinical imaging system being developed with IBM called i- SCORE, to improve and expedite the transfer of patient image files.

The IT & Informatics category was particularly strong. Convey Computer nominated a team at UCSD, for InsPecT, a fast database search tool for post-transitional modified mass spectrometry spectra. The Translational Genomics Research Institute (TGen) has developed the BIOMAP repository for the Integrated Biobank of Luxembourg.

On the High-Performance Computing side, there were strong entries nominated by companies such as Cycle Computing (Purdue), DataDirect Networks (Cornell), FalconStor Software (Baylor College of Medicine), Isilon Systems (Oklahoma Medical Research Foundation) and Panasas (Uppsala University). TGen also described its experiences building its next-gen data processing pipeline.

The Clinical Trials and Research category was populated with many successful vendor/pharma partnerships, ranging from dashboards and electronic data capture tools to a graphical user interface for trial designs.

As always, we thank everyone who participated in the 2010 competition, and not just the folks who are deservedly spotlighted elsewhere in this issue. We encourage everyone working on bold, imaginative solutions for managing research and data to consider entering their story when we open the gates for the 2011 competition in a few months' time.

[Sidebar]

The CEOs of the sponsors Tessella (Grant Stephan, left) and GenomeQuest (Ron Ronauro, right) helped bestow the 2010 Best Practices Awards last April.

[Sidebar]

September Special

The next issue of Bio*IT World (September/October) will feature a special report on the march to the $1,000 genome. It will include reports and interviews on many facets of the next-generation sequencing industry, from a preview of third-generation platforms to current-generation software tools, as well as profiles of some key people in the field. It will also coincide with the publication of my new book, The $1,000 Genome, published by Free Press, which has been gestating over the past three years.

Pinochet-Era Victims Exhumed in Chile

SANTIAGO, Chile - Authorities on Tuesday began exhuming the remains of dozens of victims of repression under the 1973-90 dictatorship of Gen. Augusto Pinochet in a renewed effort to determine their identities.

The remains of 13 people were unearthed with help from three foreign experts on the first day of exhumations ordered by Judge Carlos Gajardo. Some of the remains are being uncovered for a second time after the coroner's office acknowledged last year that the misidentified remains of some victims were handed to the wrong relatives.

The victims were originally buried in unmarked tombs at Santiago's General Cemetery in the first few weeks after the bloody 1973 coup led by Pinochet. Some coffins contained the remains of two victims.

Forensic bungling during the first exhumation forced families to relive their grief and outraged the nation. The coroner's office said 48 of the 126 bodies exhumed from the cemetery since 1991 were misidentified. In 67 other cases, officials were either not able to identify the bodies or had doubts about the identities. Only 11 bodies were identified correctly.

Because of those failures, the judge decided to call three foreign experts to help with the new exhumations, said Maria Luisa Sepulveda, a social worker appointed by the government to follow the process. She said the samples of the human remains may be sent abroad for tests.

According to a report prepared by an independent commission appointed by the civilian government that succeeded Pinochet in 1990, a total of 3,190 people were killed for political reasons during his long reign, and 1,197 were arrested and never seen again.

Fewer than 200 of the missing have been accounted for properly.

Pinochet died in December at age 91.

N. Korea Vows to Denuclearize in Talks

SEOUL, South Korea - North Korea's No. 2 leader pledged his country's commitment Thursday to giving up its nuclear program amid intensifying diplomacy aimed at implementing Pyongyang's pledge to disarm.

"The denuclearization of the Korean Peninsula is the dying wish" of the country's late founding president Kim Il Sung, Kim Yong Nam said in Pyongyang during a visit from a high-level South Korean delegation.

The North "will make efforts to realize it," he said.

At the meeting, South Korean Unification Minister Lee Jae-joung pressed the North to implement a Feb. 13 pledge made with the U.S. and four other countries to take initial steps to disarm.

"It is important to make efforts to ensure that South and North Korea cooperate and six countries each assume their responsibilities," Lee said.

Kim Yong Nam also called on the Koreas to cooperate to achieve the reunification of the peninsula, which was divided in the wake of World War II and still remains technically at war since the 1950-53 Korean War ended in a cease-fire.

Kim also repeated the North's calls for inter-Korean collaboration, an idea South Korea has dismissed as a ploy to drive a wedge in Seoul's alliance with Washington.

This week's Cabinet-level talks between the North and South - the highest-level regular contact between the Koreas - are the first in seven months. The talks resumed after North Korea's agreement last month in Beijing to shut down its main nuclear reactor within 60 days in exchange for aid.

Earlier Thursday, North Korean negotiators appealed for aid from the South, but Seoul appeared resistant to promising any major assistance until Pyongyang keeps its pledge to start dismantling its nuclear program.

"The North side has brought up the issue of humanitarian aid," a South Korean official told reporters in Pyongyang, where talks between the two Koreas stretched into a third day.

But the official, indicating the South's reluctance to provide the North with badly needed supplies, said that a draft agreement between the two sides "does not specifically mention rice and fertilizer aid." The official did not give his name due to the sensitivity of the ongoing talks.

South Korea had regularly sent aid to the impoverished North until last July, when Pyongyang test-fired a series of missiles, prompting a halt in shipments. Relations between the two countries further soured after the North tested a nuclear weapon in October.

North Korea also has proposed that the two countries resume economic cooperation talks in March, but Seoul was apparently opposed to holding the talks so soon, according to pool reports.

The two Koreas have made historic strides toward reconciliation after their leaders met for the first time in 2000, and this week's talks are the 20th such Cabinet-level meeting since then.

On Thursday, South Korean President Roh Moo-hyun stressed the nuclear deal "should be successfully implemented so that a peace regime can be firmly established on the Korean peninsula."

The Feb. 13 deal calls for a separate forum on discussing a peace agreement to replace the cease-fire that has held the Korean War at a standstill since 1953.

Meanwhile, the countries involved in the nuclear talks - the Koreas, China, Japan, Russia and the U.S. - have begun preparations to implement the disarmament pact.

In Washington, State Department spokesman Sean McCormack said that U.S. and North Korean officials will meet in New York next Monday and Tuesday to discuss normalizing relations, one of the steps to be taken under the nuclear deal.

Also Thursday, the State Department's No. 2 diplomat, John Negroponte, arrived in Japan for a tour expected to focus on the North Korea nuclear issue that will also take him to South Korea and China.

South Korean Foreign Minister Song Min-soon also left for Washington Thursday for talks on North Korea with his counterpart, Secretary of State Condoleezza Rice. He also will travel to Moscow.

---

Associated Press Writer Bo-mi Lim contributed to this report.

Monday, March 12, 2012

Correction: Box Office story

In a Nov. 23 story about the weekend box office, The Associated Press erroneously reported the last name of the president of distribution for Summit Entertainment, which released "Twilight." His name is Richie Fay, not Say.

'Holistic' approach to risk management

Maybe financial service companies should re-evaluate structures

Financial services companies should re-evaluate their risk management structures in favor of a more practical and holistic approach, according to a new report published recently by PricewaterhouseCoopers and the Economist Intelligence Unit (EIU).

Taming Uncertainty: Risk Management for the Entire Enterprise highlights the range of risks facing financial institutions, from high to low probability and from the quantifiable to the intangible. The report also provides an insight into what industry leaders are doing to ensure they understand the risks they face, and to align their risk management strategy with their corporate objectives.

Juan Pujadas, leader of the global financial risk management practice, PricewaterhouseCoopers said, "There can be a tendency for risk to be concentrated into stand-alone silos. Many banks split risk into three deceptively neat areas of credit, market and operational risk, for example, and set up departments to deal with each, rather than accepting that may of these risks are interlinked.

A comprehensive and integrated view of risk, and a dynamic process for managing risk, are essential components of a leading-edge risk management ca abilitv."

A number of factors need to coalesce in order to create the right framework for holistic risk management:

- Board level management must seize the risk management agenda and make risk management a strategic priority.

- Management processes need to be set up to ensure that an awareness of risk informs corporate governance, decision-making, external reporting and compensation.

- The right enablers - the people and systems that facilitate risk management decisions - must be put in place to deliver the information upon which managers can base their decisions.

Pujadas adds, "In an environment where risks permeate every aspect of the enterprise and where low probability, high impact events are grabbing headlines with increasing regularity, ignoring them is not an option. A regular and objective assessment of a company's own internal risk management framework and increased attention to the risks created through dealings with other institutions, whose risk management structures may not be as robust, are crucial."

As part of the study, PricewaterhouseCoopers identifies 10 attributes of a world-class risk management culture:

1. An awareness of risk and the need to manage it pervades the enterprise.

2. Risks are identified, reported and quantified to the greatest possible extent.

3. Equal attention is paid to both quantifiable and unquantifiable risks.

4. Risk management is everyone's responsibility and is not fragmented into compartments and silos.

5. Everyone involved in monitoring risk, even non-financial risk, has a power of veto over new projects they consider too risky.

6. The enterprise avoids products and businesses it does not understand.

7. Scenario planning embraces uncertainty and factors all possible developments into decision making

8. Risk managers are monitored. Internal audit procedures ensure that systems are running properly and the right results are being reported.

9. Risk management is recognized as a key contributor to value creation.

10. The risk culture is defined and enshrined to give managers and employees the requisite freedom of maneuver to deliver long-term growth and value.

Jeremy Scoff, global head of financial services at PricewaterhouseCoopers said, "The prize that awaits leading risk managers is not simply an avoidance of losses but more importantly, increased shareholder value.

Chief executives who understand risk when making strategic decisions and who clearly communicate their risk appetite inside and outside the company have the best chance of striking the right balance between risk and reward which is fundamental to value creation and profitable growth."

Padres 2, Mets 1, 10 innings

t Ld-Writethru,0374Padres 2, Mets 1, 10 innings
NEW YORK @ SAN DIEGO @
ab r h bi @ab r h bi
JReyes ss 5 0 0 0 Hirston cf 5 1 2 1
LCstillo 2b 4 0 1 0 EGnzlz 2b 3 0 0 0
DWrght 3b 5 0 1 0 Giles rf 3 0 2 0
Beltran cf 5 1 1 0 AdGzlz 1b 4 0 1 0
Dlgado 1b 4 0 3 0 Kzmnff 3b 3 0 0 0
Tatis lf 4 0 0 0 Greene ss 2 0 0 0
DSnchz p 0 0 0 0 JHuber lf 2 0 0 0
Csnova ph 1 0 0 0 TClark ph 1 0 0 0
Flciano p 0 0 0 0 Banks pr 0 0 0 0
EnChvz rf 3 0 1 1 Corey p 0 0 0 0
Schndr c 2 0 1 0 Bell p 0 0 0 0
OlPrez p 3 0 0 0 McAnlt ph 1 0 0 0
JoSmth p 0 0 0 0 MAdams p 0 0 0 0
Schnws p 0 0 0 0 Barrett c 4 1 1 1
Easley lf 1 0 0 0 Baek p 2 0 0 0
Gerut cf 2 0 0 0
Totals @ 37 1 8 1 Totals @32 2 6 2
New York 010 000 000 0_1
San Diego 000 010 000 1_2
No outs when winning run scored.
E_JHuber (1). DP_New York 1, San Diego 1. LOB_New York 11, San Diego 8. 2B_LCastillo (6), Delgado (10), Giles (19). HR_Hairston (9), Barrett (1). SB_LCastillo (10), EnChavez (1). SF_EnChavez.
IP H R ER BB SO
New York @
OlPerez 5 1-3 4 1 1 2 5
JoSmith 2-3 0 0 0 0 1
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Feliciano L,0-2 0 1 1 1 0 0
San Diego @
Baek 6 7 1 1 2 2
Corey 2 0 0 0 0 1
Bell 1 1 0 0 0 2
MAdams W,1-0 1 0 0 0 2 2
Feliciano pitched to 1 batter in the 10th.
HBP_by JoSmith (Greene), by OlPerez (Kouzmanoff), by OlPerez (Giles).
Umpires_Home, Mike WintersFirst, Laz DiazSecond, Wally BellThird, Paul Schrieber.
T_3:07. A_38,972 (42,691).

Systematic Function-Based Intervention for Adolescents with Emotional and Behavioral Disorders in an Alternative Setting: Broadening the Context

ABSTRACT:

Three adolescents (ages 14-17) with emotional and behavioral disorders displayed chronic disruptive behavior in their self-contained classrooms at a self-contained alternative school. A descriptive functional behavioral assessment was conducted for each student. Data from file review, structured interviews, and direct observations were used to identify the functions of their disruptive behaviors. Then, function-based interventions were systematically constructed for each student and implemented for an extended period (nearly 6 weeks) within the most problematic situation in their classrooms. The interventions improved each student's behavior and the effects maintained during follow-up and generalized to instruction in a nonintervention classroom. Social validity data comparing the interventions to baseline practices revealed the function-based intervention had moderately higher social validity among teachers and substantially higher social validity among students.

Alternative schools began to emerge in the 1960s with a goal of providing education to students who could not "succeed" in regular school settings (Raywid, 1999). The National Center for Educational Statistics (NCES) reported there were 3,850 public alternative schools in the 1997-1998 academic year (NCES, 2002). By 2002, the number had nearly tripled to at least 11,000 public alternative schools (Kleiner, Porch, & Farris, 2002). Chronic behavioral difficulty was the primary reason for placement in an alternative setting (Kingery, 2000, 2001; Kleiner et al., 2002; Skiba & Peterson, 1999).

The number of students with emotional and behavioral disorders (EBD) who are educated in a separate facility is three times higher than that of students with other disabilities (U.S. Department of Education, 2006). Increasing numbers of these students are being placed in alternative schools (Cox, 1999; Franklin, 1992; Gregg, 1999; Lehr, Moreau, Lange, & Lanners, 2004; Tobin & Sprague, 2000). Currently, more than 20% of students with EBD are placed outside of their mainstream school, and greater than 52% spend at least 60% of their time outside of a regular educational setting.

Before placing a student with a disability in an alternative educational setting, federal law (Individuals with Disabilities Education Act, 1997; Individuals with Disabilities Education Improvement Act, 2004) requires that a functional behavioral assessment (FBA) must be conducted. Functional behavioral assessment is a method for gathering information that identifies the function of a problem behavior and the events that predict when it will occur (Sugai et al., 2000). Specifically, the FBA identifies (a) the antecedent conditions present when the behavior occurs and when it does not occur and (b) the consequences that maintain the behavior. Function-based intervention refers to the development of behavior change strategies, based on the FBA data, which directly address the problem behavior's function.

Considerable research (see reviews by Fox, Conroy, & Heckaman, 1998; Fox & Gable, 2004; Heckaman, Conroy, Fox, & Chait, 2000; Kern, Hilt, & Gresham, 2004; Lane, Karlberg, & Shepcaro, 2009; Sasso, Conroy, Stichter, & Fox, 2001; Wood, Umbreit, Liaupsin, & Gresham, 2007) has pointed to the effectiveness and durability of function-based intervention. These studies have been conducted with students and adults of all ages, with individuals with various disabilities, in a variety of settings, and with various problematic behaviors. Ironically, only one study (Turton, Umbreit, Liaupsin, & Bartley, 2007) has reported on the effectiveness of function-based intervention in supporting adolescents with EBD once they are in an alternative setting. Turton and colleagues conducted an FBA and then used a function-based intervention package to reduce a student's use of profanity and increase her use of appropriate social responses during instructional activities. Social validity ratings completed by multiple classroom staff, the student, and a student peer were positive.

The purposes of this study were to further examine the efficacy of function-based intervention to support adolescents with EBD placed in an alternative educational setting, to expand the data collected to include both generalization and maintenance probes, and to assess the social validity of the interventions. The study was conducted in two phases. In Phase 1, descriptive FBAs were conducted for each student. Each FBA included file review, structured interviews, and direct observations to identify the functions of target behaviors. In Phase 2, function-based interventions were systematically constructed for each participant and then implemented in the classroom during the activity the teacher identified as being the most problematic. Data were collected daily for nearly 6 weeks (29 sessions) and for 3 days during a single week 3 weeks after intervention concluded. Generalization probes were conducted weekly in nonintervention classes once each student's intervention began and during the maintenance sessions.

General Method

Participants and Setting

The setting was a self-contained Pre-K-12 alternative day school program for students with EBD, mild or moderate disabilities, or autism. Severe challenging behavior was the common denominator underlying each student placement. The school's stated mission was to foster development of appropriate behavioral coping skills, relevant academic knowledge, and proper motivation to facilitate a successful return to a comprehensive campus. All classrooms covered the academic areas typical for the grade level. The difficulty level of the work was often modified because most students were behind academically, presumably because of their behavioral problems, which interfered with the delivery of instruction. Each classroom was staffed by a teacher and an instructional aide.

The school employed a school-wide system in which students earned points for meeting behavioral expectations. Points were exchangeable for special privileges such as participating in "Fun Friday." Once students met behavioral criteria determined by their individualized education plan and the appropriate level of points, they were considered ready to begin phasing back into a comprehensive neighborhood school campus. This was done slowly, one subject (e.g., math), day (e.g., Mondays), or specific teacher at a time, beginning with mainstreammg within the alternative school (moving from being in one class all day to different classes according to the subject), and then progressing to mainstreaming to classes at the home school, until the student was fully transitioned.

Participants were three White boys and their respective teachers (two White women and one White man). Tahir, age 1 5, attended a 9th-grade class of 22 taught by Ms. A, who had 1 year of teaching experience. Cain, age 17, attended a 12th-grade class of 8 taught by Mr. B, who had 5 years of teaching experience. James, age 1 4, attended an 8th-grade class of 7 taught by Ms. C, who had 8 years of teaching experience. All three teachers had degrees in special education and were certified to teach students with EBD. Their preparation had included coursework on FBA and managing challenging behavior in classrooms.

These participants were selected through a series of phases. First, the first author met with all teachers and staff who worked at the high school level to identify all students who remained resistant to the school's point system and had received an average of at least one office referral per week. Second, each teacher identified his or her most difficult student. Finally, the teachers and staff met again to determine, from their perspective, the feasibility of participation; this process resulted in identifying for this study the only three high school students who were not participating in any level of mainstreaming.

Behavioral Definitions

All three students exhibited behaviors that were considered to be disruptive to their learning or that of others. The topography of each student's behavior varied. "Disruptive behavior" was defined globally as a group of behaviors that interfered with a student's access and his peers' access to instruction. For Tahir, disruptive behaviors included making inappropriate comments, particularly sexual comments, about himself or others. For Cain, disruptive behavior included refusing to comply with directions (e.g., saying "No" or just continuing with a different activity), throwing books or chairs, banging on desks or walls, and screaming profanities. For James, disruptive behaviors included using profanity and making verbal threats. For all three students, the replacement behavior was on-task, defined as sitting in his seats, engaging in the assigned task, and asking for help appropriately (raising his hand, waiting, stating what he needed, e.g., "I don't understand how to do this math problem").

Phase 1: FBA

Procedure

A descriptive FBA was conducted for each student to identify the antecedent conditions that set the occasion for his target behaviors and the consequences that maintained these target behaviors. Data were collected via file review, staff and student interviews, and direct observation in the classroom. These data were then analyzed to identify the function(s) of each student's target behaviors and the most critical situations in which interventions should occur.

File Review

A comprehensive file review was conducted for each student. Specific information reviewed included prior record of discipline referrals and suspensions, daily points earned for positive interactions, time spent out of class in time-out or in-school suspension), anecdotal comments from current or prior teachers, school attendance history, and informal and formal academic assessment results.

Staff Interviews

Structured interviews were completed with the classroom teacher and instructional aide in each class. Interviews followed the Preliminary Functional Assessment Survey (Dunlap et al., 1993), a 22-item survey developed to solicit important information about functional relationships between the environment and student behavior. The survey also solicits information about medical conditions that may affect behavioral regulation, the impact of distal antecedent events (e.g., missed breakfast, conflict with family or peer), and rough estimates of the frequency and duration of the behavior.

Structured Student Interview

The Student Assisted Functional Assessment Interview (Kern, Dunlap, Clarke, & Childs, 1994) was conducted with each student. This instrument solicits information about what the student believes triggers and maintains his inappropriate behaviors, when he has the most and the least problems in school, what he thinks causes these problems, and how he thinks the situation could be changed for the better. The student also rates preferences for specific subjects and his own skill level relative to the work assigned. Finally, the child responds to questions about working conditions, teacher presentation, and interest level in the work.

Structured Observations

Antecedent-behavior-consequence (ABC) data (Bijou, Peterson, & AuIt, 1968) were collected individually for each participant on four occasions. Each observation lasted approximately 20 min and occurred in the student's classroom during naturally occurring activities in which the target behavior was most likely to occur.

Identification of Function

The function(s) of each student's disruptive behavior was identified by analyzing the FBA data using the Function Matrix (Umbreit, Ferro, Liaupsin, & Lane, 2007), a six-celled visual tool that organizes information into two columns identifying positive or negative reinforcement and three rows identifying specific types of consequences. The tool prompts users first to determine if the student is gaining access to something (positive reinforcement), escaping/avoiding something (negative reinforcement), or both. The user then identifies more specifically whether the student is gaining or escaping attention, tangibles/activities, or sensory consequences. The Function Matrix allows the identification of multiple functions for a single target behavior. In this study, the classroom teacher and first author jointly identified function by reviewing all of the interview results and ABC data with respect to the Function Matrix.

Results

Results of the file reviews, interviews, direct observations, and the Function Matrix analyses are presented for each student.

Tahir

File review indicated that Tahir's teachers believed his poor academic achievement was not due to ability but rather to the disruptive behaviors he displayed. At the end of the previous school year, he had started the mainstreaming process in which students gradually move from teacher to teacher and subject to subject. During the summer, a traumatic event triggered a relapse of inappropriate behaviors, which led the team to reconsider placement and start him back within the self-contained classroom.

The teacher and aide were most concerned about Tahir's inappropriate comments that got other students involved in a back and forth argument or led a peer to become aggressive. Tahir also made false accusations about staff that required administrative investigations. They believed his sexual references made it easier to get a reaction from others. Tahir rarely earned enough points to participate in Fun Friday and spent much of each day in the classroom time-out area or in a study carrel away from class activity. Identified reinforcers included one-on-one time with a staff member, computer time, or a visit to other classrooms.

Tahir reported that his classwork was sometimes challenging, but usually not and that he was only sometimes rewarded for good behavior. He felt he could work better with someone assisting him, like the full-time aide he had in his previous school.

During the four ABC data collection sessions, Tahir was on-task an average of 26% (range = 0%-40%). Instances of disruptive behavior occurred when (a) a new person entered the room, (b) the teacher asked the class a question, or (c) another student was called to the office or called on to answer a question. When these antecedents occurred, Tahir would (a) get out of his seat, (b) make an inappropriate comment to a peer or staff member, and (c) make repeated comments if he did not get a reaction. In every case, he gained teacher or peer attention.

Using the Function Matrix, the teacher and first author jointly decided that the staff interviews and ABC data indicated Tahir made inappropriate remarks to gain attention from peers and teachers.

Cain

File review indicated Cain's challenging behaviors had increased over the 8 weeks prior to the beginning of the study. During his 5 years at the school, he had improved in some academic areas. Cain often had episodes in which he "lashed out," he claimed, because others were talking about him. He spent considerable time either in the classroom time-out area or in in-school suspension, either by self-initiation or teacher request.

Staff were most concerned about Cain's refusal to follow directions and his violent outbursts. Typical approaches to addressing these behaviors had been to ignore them or to suggest that he go to the time-out area or take a walk. Staff believed his behavioral problems were increasing both in intensity and frequency, and that his target behaviors always occurred when he was challenged in any way or lost points on his point sheet. Reported reinforcers included listening to music, using the computer, and eating candy or food during class time.

Cain was happy to be interviewed. Once questioning began, he would answer about four questions before speaking on a different, often unrelated topic. Cain reported his work was sometimes challenging and sometimes easy, and that classes were occasionally too long. He stated he always received help when requested and did better when he worked together with someone. He also said he was distracted by classroom activity such as side conversations and the activities of the other students.

During the ABC data collections sessions, Cain was on task an average of 1 8% (range = 5%-40%). Disruptive behavior occurred when the teacher (a) began instruction (e.g., "Please turn to chapter 7''), (b) told Cain to get back to work, or (c) told Cain he might not receive his points for appropriate behavior during the class session. When these antecedents occurred, Cain would get out of his seat, engage in an alternate activity, bang on the wall, use profanity, or accuse the teacher of picking on him. In every case, he avoided further engagement with the assigned task and usually also gained attention from both staff and peers.

Using the Function Matrix, the teacher and first author jointly determined that Cain's disruptive behaviors occurred consistently following teacher directives and enabled him to both escape the task at hand and gain attention from staff and peers.

James

File review indicated that James was in his first year at the school. At the time of the study, he attended Ms. C's homeroom class. He had previously thrown furniture and threatened self-harm but had shifted to using profanity and making verbal threats to others. James lived at home with his mother and little brother and reportedly displayed similar behavioral problems at home.

Staff described several behaviors of concern, including refusal to comply with explicit directives and putting his head down and closing his eyes during instruction. They were most concerned about his use of profanity and threats, which were most likely when the teacher held him accountable for his actions or insisted on task completion.

James reported that he did not receive help when he requested it, that class periods were too long, and that no one noticed when he did a good job or awarded him the appropriate amount of points. He thought math was interesting, but the work was not challenging enough. James' favorite activities at school were using the computer and talking with friends.

During ABC data collection, James was on-task an average of 7% (range = 0%-20%). Disruptive behavior occurred when the teacher (a) started instruction, (b) asked James to answer a question, or (c) told James he might not earn points for appropriate behavior and would have to complete his assignment after class or during lunch. When these antecedents occurred, James would get up and walk around the room, accuse the teacher of lying, and make verbal threats to anyone nearby. In every case, he avoided further engagement with the assigned task and received attention from peers or staff.

Using the Function Matrix, the teacher and first author jointly determined that the interview and ABC data indicated James engaged in disruptive behavior to simultaneously avoid doing his work and gain attention. This occurred when the teacher requested he do a specific task or redirected him with a reminder of the consequences.

Phase 2: Function-Based Intervention

In Phase 2, the FBA data were used to design a function-based intervention for each participant (Tahir, Cain, and James). The resulting interventions were then implemented for several weeks (29 sessions) during each student's most problematic class.

Procedure

Function-based interventions for each participant were developed using the systematic process described by Umbreit et al. (2007). This process begins intervention development by posing two questions: (a) Can the individual perform the replacement behavior? and (b) Do the antecedent conditions represent effective practice? The answers to these questions lead to four possible outcomes. Each outcome identifies which of three intervention methods, individually or in combination, is appropriate for a given situation.

If the individual cannot perform the replacement behavior but the antecedent conditions represent effective practice, then Method 1 : Teach the Replacement Behavior is used. If the individual can perform the replacement behavior, but the antecedent conditions do not represent effective practice, then Method 2: Improve the Environment is used. If the answer to both questions is No, then both methods must be applied. Finally, if the answer to both questions is Yes, then Method 3: Adjust the Contingencies is used.

Each intervention method has three common components: antecedents are adjusted to increase the likelihood of the replacement behavior, and reinforcement is provided when the replacement behavior occurs and is withheld (extinction) when the target behavior occurs. The intervention methods differ in the ways specific antecedent and consequent variables are manipulated to address the presenting problems.

Intervention Design

In every case, the teacher, student, and first author jointly developed the intervention. Teachers helped to answer the key questions, suggested specific antecedent changes, and helped to identify reinforcement strategies that were functionally appropriate, yet also feasible and practical within their classrooms. Students participated by reviewing and approving their proposed intervention prior to implementation.

Tahir

Tahir could perform the replacement behavior - he could remain seated and engage in the assigned tasks for extended periods when he had the teacher's attention (proximity) or when asked a question. When considering classroom practices, the teacher's expectations were clearly conveyed and reinforcement was available for meeting them, the classroom routines were well established, the lessons and materials were appropriate for the subject, and the classroom arrangement was appropriate. However, the classroom schedule and instructional pacing often set the occasion for disruptive behavior. Specifically, unstructured time within lessons allowed Tahir to listen to others' conversations and make passing comments. Using this information, the first author and teacher determined that Method 2 (Improve the Environment) was most appropriate for improving Tahir's behavior.

At the start of each class, students were supposed to spend a few minutes preparing for the upcoming instructional activity. This created a situation in which Tahir's disruptive behavior was likely to occur and be reinforced. To correct this problem, Tahir was given a specific task to help the teacher get ready for class (e.g., getting and passing out handouts or setting up a DVD to be used for instruction). Instruction began immediately afterward. Because attention was the function of Tahir's behavior, attention (e.g., notes, comments, proximity, free time to socialize, lunch with teacher) was provided when he engaged in the replacement behavior and withheld (after brief redirection) whenever the target behavior occurred.

Cain

Cain lacked the social skills needed to interact appropriately with others. Although many of the classroom practices were appropriate, he often had difficulty finding the right page in his book and worked better with a partner, but rarely had the opportunity. Therefore, the first author and teacher decided that Methods 1 (Teach the Replacement Behavior) and 2 (Improve the Environment) were both needed. .Table 2 lists the intervention components they developed.

To develop more appropriate social skills, Cain met two to three times per week with the school counselor to develop and practice these skills. To improve the antecedent conditions, the book was already opened to the right page before the lesson and a partner (initially the teacher, and later a peer) worked with Cain after he was on-task for 15 min. When the replacement behavior occurred, he received attention (e.g., praise) and then a break, that is, free time to listen to music. These reinforcers addressed the attention and escape/activity functions, respectively. When the target behavior occurred, Cain was briefly redirected and the task demand was maintained. These extinction procedures addressed the same functions.

James

James frequently completed assignments accurately and on time and often showed sustained attention to assignments. In addition, the behavioral expectations were clear and reinforced, the classroom arrangement, routines, lessons, and materials were appropriate, and instructional delivery was steady and at the proper instructional level. Because James could perform the replacement behavior and the antecedent conditions reflected effective practice, the first author and teacher determined that Method 3 (Adjust the Contingencies) should be used for intervention.

To make it more likely the replacement behavior would occur, James was given a reminder of the new contingencies for appropriate behavior at the start of class. When the replacement behavior occurred, he received attention (e.g., praise) and, after 1 5 min on-task, one-to-one support. These consequences addressed the attention function. James also received a break via a "choice" card he could exchange for various preferred activities. This addressed the escape/activities function. Instances of the target behavior received two extinction procedures - brief redirection (to address the attention function) and continuation of the task at hand (to address the escape function).

Behavioral Definitions and Measurement

The behavioral definitions used in Phase 1 were used again in Phase 2. Data on the replacement behavior (on-task) and treatment integrity were collected for every session. Each session lasted 20 min and was conducted during the activity each teacher had identified as the most problematic. Generalization probes lasting 15 min were also conducted once per week during similar activities in a separate class.

On-task behavior was measured using a 30s whole-interval recording method. Treatment integrity data were collected using the same 30s whole-interval procedure. Specifically, at the end of each interval, each observer scored a "+" if all of the required intervention components were correctly implemented throughout the entire interval. If staff failed to implement any required part of the intervention at any point during an interval, it was scored as a "-." For more information on the collection of treatment integrity via whole-interval recording, see Umbreit et al. (2007) or Wood, Umbreit, Liaupsin, and Gresham (2007).

Design

A multiple baseline design across students (Kazdin, 1982) was used. All participants began in baseline at the same time after the FBAs were completed. However, the individualized interventions were introduced at different points in time for each student, that is, on Day 5 for Tahir, Day 10 for Cain, and Day 15 for James. Data were collected 5 days per week for nearly 6 weeks (29 sessions total) in Tahir's and James's social studies classes and in Cain's language arts class (i.e., those identified by each teacher as the most problematic). Generalization probes in other classes (language arts for Tahir and science for both Cain and James) were collected weekly once intervention began for each student. Follow-up data, including generalization probes, were collected for three sessions for Cain and Tahir, and two for James (due to absence) during a single week, 3 weeks after intervention concluded.

Interobserver Agreement (IO A)

Interobserver agreement data were collected by having a second observer independently record data on the replacement behavior and treatment integrity. Interobserver agreement data were collected in each condition for each student. Depending on the student, IOA data were collected for 33%50% of the baseline sessions, 38%-71 % of the intervention sessions, 33%-100% of the maintenance sessions, and 33%-100% of the generalization probes.

Interobserver agreement was assessed using the exact interval-by-interval method (Kazdin, 1982). Each interval scored identically was considered an agreement. Interobserver agreement was calculated by dividing the number of agreements by the total number of intervals and multiplying by 100%.

For the replacement behavior, IOA averaged 95% (range = 80%-100%) for Tahir, 90% (range = 75%-100%) for Cain, and 90% (range = 80%-1 00%) for James. For treatment integrity, IOA averaged 94% (range = 90%100%) for Tahir, 95% (range = 90%-100%) for Cain, and 94% (range = 85%-100%) for James.

Social Validity

Each teacher and student assessed social validity before and after intervention. The first administration occurred at the start of baseline and assessed the conditions in effect during baseline. The second, conducted at the end of the intervention phase, assessed the functionbased intervention. On each occasion, each teacher independently completed the Behavior Intervention Rating Profile (BIRP; Martens, Witt, Elliott, & Darveaux, 1985). The BIRP includes six questions that address whether an intervention targets an important goal, is warranted and reasonable within the classroom, and is likely to or did improve behavior. Each item is rated on a 6-point Likert-type scale ranging from 1 (strongly disagree) to 6 (strongly agree). Scores range from 6 to 36, with higher scores indicating higher social validity. Each student independently completed the Children's Intervention Rating Profile (CIRP; Witt & Elliott, 1985), a 7-item instrument that addresses whether the intervention was fair, helpful, acceptable, appropriate with other students, and likely to cause problems with the target student's friends. Each item is rated on a 6-point Likert-type scale ranging from 1 (strongly disagree) to 6 (strongly agree). Scores range from 7 to 42, with higher scores indicating higher social validity.

Results

Figure 1 shows that each student's on-task levels were low during baseline, increased during intervention, maintained during the follow-up period, and generalized to the secondary class setting. Specifically, Tahir's on-task behavior averaged 28% (range = 10%-50%) during baseline, increased to an average of 93% (range = 70%-100%) during intervention, and maintained at an average of 97% (range = 90%-100%) during follow-up. During generalization probes, the average was 92% (range = 80%-100%). There were no overlapping data points between the baseline and intervention conditions.

Cain averaged 24% (range = 0%-60%) during baseline compared to 90% (range = 75%-100%) during intervention, 97% (range = 90%-100%) during follow-up, and 94% (range = 75%-100%) during the generalization probes. There were no overlapping data points between baseline and intervention.

James averaged 11% (range = 0%-37%) during baseline compared to 86% (range = 48%-100%) during intervention, 95% (range = 90%-100%) during follow-up, and 100% during the generalization probes. There were no overlapping data points.

Treatment integrity (see Figure 1) during baseline was 0% for all teachers, indicating the interventions were not implemented. During intervention, Ms. A averaged 94% (range = 90%-100%), Ms. B 91% (range = 80%100%), and Ms. C 94% (range = 85%100%). During follow-up, teachers independently maintained these levels at 87%, 97%, and 89%, respectively.

The teachers' social validity ratings on the BIRP averaged 30.3 (of 36; range = 28-33) for the baseline conditions and 32.7 (range = SI36) for the intervention. The students' ratings on the CIRP averaged 27 (of 42; range = 2430) for the baseline conditions and 36.7 (range = 35-40) for the intervention.

Discussion

Systematically constructed function-based interventions were implemented with three adolescents with EBD who were placed in an alternative educational program because of their challenging behavior. The interventions improved the behavior of each student, and the effects maintained during follow-up and generalized to instruction in a nonintervention classroom. Assessments conducted at the start of baseline and at the end of intervention revealed the function-based intervention had moderately higher social validity among teachers and substantially higher social validity among students.

This study contributes to the literature in several ways. First, it adds to the broader literature supporting the efficacy and social validity of function-based intervention. Second, it adds to the literature on the effectiveness of function-based intervention in supporting adolescents with EBD once they have been placed in an alternative educational setting. Third, it extends the work of Turton et al. (2007) by providing additional data on both maintenance and generalization. Finally, it provides additional data supporting the effectiveness of the systematic process for designing function-based interventions that was described by Umbreit et al. (2007). The findings here are consistent with previous studies examining this process (e.g., Lane, Rogers, et al., 2007; Lane, Weisenbach, Phillips, & Wehby, 2006; Lane, Weisenbach, Little, & Wehby, 2007; Liaupsin, Umbreit, Ferro, Urso, & Upreti, 2006; Nahgahgwon, Umbreit, Liaupsin, & Turton, in press; Stahr, Cushing, Lane, & Fox, 2006; Umbreit, Lane, & Dejud, 2004; Underwood, Umbreit, & Liaupsin, 2009; Wood et al., 2007).

All three students engaged in disruptive behaviors. Depending on the student, these behaviors served different functions and required different intervention methods. Nonetheless, a positive outcome was obtained in each case. This finding adds support for the breadth and flexibility of the process of function-based intervention.

Peterson and El I ison (2005) reported a correlation between level of social validity and the likelihood of continuing to implement an intervention. In this study, teachers maintained high levels of treatment integrity during the follow-up phase, when implementation of the intervention was no longer required. The fact that each teacher independently continued to implement the function-based intervention when it was no longer required is the best indication of its social validity.

Certain limitations should be noted. First, the teachers who participated in this study had previous training in classroom management and FBA and previous experience teaching adolescents with EBD. This likely influenced their ability to contribute to intervention development. It also could have influenced how quickly they learned to implement the interventions with high levels of integrity. Different results might occur with less sophisticated staff.

Second, the target behavior - disruptive behavior - was not measured directly during intervention. In addition, the replacement behavior - on-task behavior - might best be considered an appropriate alternative behavior that is incompatible with disruptive behavior. Because a whole-interval method was used to measure on-task behavior, the level of disruptive behavior could never be higher than the level of off-task behavior. Nevertheless, a student might be off task without engaging in disruptive behavior. For this reason, it would be preferable in future research to simultaneously record on-task behavior using a whole-interval measure and disruptive behavior using a partial-interval measure. These methods would provide direct data on on-task, off-task, and disruptive behavior.

Third, the extinction procedure for all three students included brief redirection to address the attention function of their disruptive behaviors. Redirection, even if it is brief (e.g., "Do your work"), provides some attention, although a minimal amount compared to the amount their disruptive behaviors normally received. In addition, each teacher was concerned that completely ignoring the behavior might lead each student to escalate it. For these reasons, brief redirection was included as one of the extinction procedures for each student. It is possible that completely ignoring the behavior would have been equally effective.

Fourth, the interventions were designed collaboratively by a researcher (the first author), each teacher, and each student. Although collaboration between researcher and teacher has been reported previously (cf. Lane et al., 2007), participation by the involved student is a new element. Despite the collaboration, a consultant/expert model (cf. Bergan & Kratochwill, 1990) was clearly used in this research. Prior research (e.g., Scott et al., 2005) has suggested that, without expert support, practitioners typically return to the types of assessment and intervention methods with which they are most comfortable. Whether or not the teachers, individually or with their students, could have independently designed equally effective interventions is an area for future research.

Fifth, the improvement in pre- and postintervention social validity ratings was proportionally much greater for the students than for the teachers. Both groups gave high ratings to the function-based intervention. The difference in proportional change occurred because teachers gave much higher ratings to the baseline conditions than did the students directly affected by these practices. If both the teachers and the students had reassessed the baseline conditions after intervention, different results might have been obtained.

Sixth, generalization probes were conducted in another class setting once intervention started for each student. It would have been preferable to have conducted these probes during baseline, as well, but this was not possible. Tahir, Cain, and James were the only high school students in the school who received all of their instruction in their primary classroom. Once intervention began, each was able to earn enough points to begin the mainstreaming process within the school. The influence of this added reinforcer is unknown.

Finally, the interventions examined here were implemented during a limited portion of each student's school day. Nothing can be said about their effects on behavior at other times, when a different function of behavior might emerge and different intervention procedures might be required. Regardless, the success of these interventions raises questions about the potential of function-based support if it were provided throughout the school day. One must consider whether this approach, if implemented extensively, has the potential to prevent the need for alternative placement outside the mainstream.

Despite these limitations, the data reported here clearly point to the potential power of function-based intervention as a support for adolescents with significant behavioral challenges. The students studied here were the least successful among a group of students already placed in an alternative school because of their behavioral problems. Furthermore, the assessments and interventions targeted these students' most problematic situations in school. Nevertheless, their behavior improved, maintained, and generalized to a nonintervention classroom. Equally important, the interventions were deemed socially valid by those most directly involved - the students themselves - and were maintained by their teachers even after the study ended.

Future studies are needed to examine whether function-based support can prevent the need for alternative placement or, after placement, facilitate transition back to the mainstream. This effort will be aided by studies of function-based intervention extended throughout the school day and over longer periods of time. Studies are also needed to better document generalized effects by including data from multiple contexts during baseline, intervention, and follow-up. Research with staff less sophisticated than those who participated here may shed light on ways in which both staff and students can participate in intervention development more routinely and even more productively.

[Reference]

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[Author Affiliation]

Amina M. Turton

University of Alaska, Anchorage

John Umbreit

University of Arizona

Sarup R. Mathur

Arizona State University

[Author Affiliation]

AUTHORS' NOTE

The work reported here was supported in part by U.S. Department of Education Grant H325D040019.

Address correspondence to Amina M. Turton, Assistant Professor, Counseling and Special Education, College of Education, University of Alaska Anchorage, Professional Studies Building, 206B, 3211 Providence Drive, Anchorage, AK 99508.

MANUSCRIPT

Initial Acceptance: 6/21/10

Final Acceptance: 7/12/10